Publications
All papers available on Google Scholar.
How do cell types diverge and phenotypes converge? We identified white pigment cells in zebrafish that also use pteridines to generate white ornamentation.
Delai Huang, Tiffany Liu, Augusr A Carr, Pietro H de Mello, Yipeng Liang, Leah Shriver, François Chauvigné, Stephen L Johnson, Joan Cerdà, Gary J Patti, David M Parichy
We identified the mechanism of biased yellow vs. red coloration. Using CRISPR-Cas9, we generated all red fish, which is preferred by females in shoaling assays.
Delai Huang, Pietro L. H. de Mello, Tiffany Liu, Yu Liu, Emaan H. Kapadia, Yipeng Liang, Jianguo Lu, Joseph C Corbo, David M Parichy
How do cell types convert? We identified signaling pathways/transcription factors involved in melanophore trans-differentiation to leucophore in zebrafish.
Delai Huang, Emaan H Kapadia, Yipeng Liang, Leah P Shriver, Shengkun Dai, Gary J Patti, Bruno M Humbel, Vincent Laudet, David M Parichy
How do cell types convert? We identified signaling pathways/transcription factors involved in melanophore trans-differentiation to leucophore in zebrafish.
Yayue Chen(co-first), Delai Huang(co-first), Aixuan Xie, Ying Shan, Shuyi Zhao, Ce Gao, Jun Chen, Hui Shi, Weihuan Fang, Jinrong Peng
Journal of Genetics and Genomics (2024)
How do fish make red pigment? We identified enzymes that convert yellow carotenoids to red, using zebrafish relative D.albolineatus (pearl danio).
Delai Huang, Victor M Lewis, Tarah N Foster, Matthew B Toomey, Joseph C Corbo, David M Parichy
Def-CAPN3 pathway serves as a nucleolar checkpoint for cell proliferation by selective inactivation of cell cycle-related substrates during organogenesis.
Yihong Guan(co-first), Delai Huang(co-first), Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen, Jinrong Peng
Selected publications
Cell type diversification and phenotype convergence underlying white fin-ornamentation of cyprinid fishes
Delai Huang, Tiffany Liu, Augusr A Carr, Pietro H de Mello, Yipeng Liang, Leah Shriver, François Chauvigné, Stephen L Johnson, Joan Cerdà, Gary J Patti, David M Parichy
PNAS (2026)
Graded BMP signals modulate yellow and red color in fishes impacting adult pigment pattern and behavior
Delai Huang, Pietro L. H. de Mello, Tiffany Liu, Yu Liu, Emaan H. Kapadia, Yipeng Liang, Jianguo Lu, Joseph C Corbo, David M Parichy
Current Biology (2026)
Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish
Delai Huang, Emaan H Kapadia, Yipeng Liang, Leah P Shriver, Shengkun Dai, Gary J Patti, Bruno M Humbel, Vincent Laudet, David M Parichy
PNAS (2025)
Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1
Yayue Chen(co-first), Delai Huang(co-first), Aixuan Xie, Ying Shan, Shuyi Zhao, Ce Gao, Jun Chen, Hui Shi, Weihuan Fang, Jinrong Peng
Journal of Genetics and Genomics (2024)
An 86 amino acids motif in CAPN3 is essential for formation of the nucleolus-localized Def-CAPN3 complex
Feng Ding(co-first), Delai Huang(co-first), Mingyun Wang, Jinrong Peng
Biochemical and Biophysical Research Communications (2022)
Nucleolus-localized Def-CAPN3 protein degradation pathway and its role in cell cycle control and ribosome biogenesis
Shuyi Zhao(co-first), Delai Huang(co-first), Jinrong Peng
Journal of Genetics and Genomics (2021)
Development and genetics of red coloration in the zebrafish relative Danio albolineatus
Delai Huang, Victor M Lewis, Tarah N Foster, Matthew B Toomey, Joseph C Corbo, David M Parichy
eLife (2021)
Phosphorylation of Def regulates nucleolar p53 turnover and cell cycle progression through Def recruitment of Calpain3
Yihong Guan(co-first), Delai Huang(co-first), Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen, Jinrong Peng
Plos Biology (2016)